The Protective Effects of Lactoferrin Feeding against Endotoxin Lethal Shock in Germfree Piglets .

Wang J. Lee,1, Jeffrey L. Farmer,2 Milo Hilty,3 and Yoon B. Kim1,*

Finch University of Health Sciences/The Chicago Medical School, North Chicago,1 and Abbott Laboratories, Abbott Park,2 Illinois 60064, and Ross Laboratories, Columbus, Ohio 432153

Received 10 November 1997/Returned for modification 22 December 1997/Accepted 15 January 1998 The unique germfree, colostrum-deprived, immunologically "virgin" piglet model was used to evaluate the ability of lactoferrin (LF) to protect against lethal shock induced by intravenously administered endotoxin. Piglets were fed LF or bovine serum albumin (BSA) prior to challenge with intravenous Escherichia coli lipopolysaccharide (LPS), and temperature, clinical symptoms, and mortality were tracked for 48 h following LPS administration. Prefeeding with LF resulted in a significant decrease in piglet mortality compared to feeding with BSA (16.7 versus 73.7% mortality, P

Infect. Immun., 12 1995, 4917-4920, Vol 63, No. 12

Copyright © 1995, American Society for Microbiology

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